Cajun Chicken Mac and Cheese

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If comfort food had a spicy Southern cousin, it would be this Cajun Chicken Mac and Cheese. Creamy, cheesy pasta meets bold Cajun-seasoned chicken for a dish that feels both indulgent and soul-satisfying. Every bite brings a punch of smoky heat balanced by rich, melty cheese—perfect for those nights when you’re craving something cozy with attitude.

This is not your typical mac and cheese. It’s built for flavor lovers who want more than just noodles and cheese. The Cajun spices wake up your palate, while tender bites of seared chicken bring a hearty twist. It’s a one-pan dinner that delivers the ultimate fusion of spice, creaminess, and Southern charm.

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What Kind of Chicken Should I Use?

Boneless, skinless chicken breasts or thighs work best for this recipe. Thighs offer more moisture and flavor, but breasts give that clean, lean bite. Cut them into bite-sized pieces so they cook evenly and soak up all the bold Cajun spices. Pre-cooked rotisserie chicken can also be used in a pinch—just add it after the pasta is done cooking so it doesn’t dry out.

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Ingredients for the Cajun Chicken Mac and Cheese

• 1 lb elbow macaroni (or pasta of choice)
• 1 lb boneless, skinless chicken breasts or thighs, diced
• 1 tbsp Cajun seasoning (plus extra to taste)
• 2 tbsp olive oil
• 3 tbsp butter
• 3 cloves garlic, minced
• 2 tbsp all-purpose flour
• 3 cups whole milk
• 1 cup chicken broth
• 2 cups shredded sharp cheddar cheese
• 1 cup shredded Monterey Jack cheese
• 1/2 cup grated Parmesan cheese
• Salt and pepper, to taste
• Fresh parsley (optional, for garnish)

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How To Make the Cajun Chicken Mac and Cheese

Step 1: Season and Cook the Chicken

Toss your diced chicken in Cajun seasoning until well-coated. Heat olive oil in a large skillet over medium-high heat. Add chicken and sear until golden and cooked through, about 6–8 minutes. Remove and set aside.

Step 2: Make the Roux

In the same skillet, reduce heat to medium. Melt butter and stir in minced garlic. Add flour and whisk constantly for 1–2 minutes until it forms a golden roux.

Step 3: Build the Sauce

Slowly whisk in milk and chicken broth. Bring to a simmer and stir until the sauce thickens, about 4–5 minutes. Season with salt, pepper, and a pinch more Cajun seasoning if desired.

Step 4: Add the Cheese

Reduce heat to low. Stir in cheddar, Monterey Jack, and Parmesan cheeses until smooth and melty.

Step 5: Combine Pasta and Chicken

Add the cooked pasta and reserved chicken to the skillet. Stir until everything is coated in the luscious cheese sauce. Warm through and serve hot.

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Serving and Storing This Spicy Pasta Dish

Serve this Cajun Chicken Mac and Cheese fresh off the stove, garnished with chopped parsley and a light extra sprinkle of Cajun seasoning if you like it fiery. It’s perfect on its own, or alongside a crisp green salad to balance the richness.

Leftovers store well in an airtight container in the fridge for up to 4 days. Reheat gently on the stovetop or microwave with a splash of milk to loosen the sauce.

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Frequently Asked Questions

How spicy is Cajun seasoning?

It depends on the brand, but most blends are medium-spicy. You can always adjust the heat by using less or mixing with a mild paprika.

Can I make it ahead of time?

Yes! Make the full dish, let it cool, and refrigerate. Reheat with a bit of milk to restore creaminess.

Can I freeze Cajun Chicken Mac and Cheese?

While technically you can, the cheese sauce may separate when reheated. It’s best enjoyed fresh or from the fridge.

What cheeses can I substitute?

Feel free to mix in mozzarella, pepper jack, or even smoked gouda for extra flair.

Is this recipe gluten-free?

Not as written, but you can use gluten-free pasta and flour alternatives to adapt it.

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Want More Comfort Food Dinners with a Kick?

If you’re into creamy, cheesy dinners that don’t hold back on flavor, check out these favorites:

• Creamy Garlic Chicken Breasts
• Creamy Crockpot Chicken Spaghetti
• Marry Me Chicken Pasta
• Cheese Shrimp Penne Pasta with Spinach
• Creamy Cajun Steak Alfredo

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Save This Pin + Share Your Results

📌 Save this recipe to your Pinterest dinner board so you can bring the heat on your next comfort food night.

And if you made this spicy, cheesy delight—tell me how it went! Did you toss in some extra Cajun heat? Swap in a different cheese? I’d love to hear your twists.

You can also find and share daily recipes on my Pinterest: Nina Dishes on Pinterest

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