Cajun Chicken Spaghetti in Creamy Garlic Mozzarella Sauce

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Rich, spicy, and creamy all at once, this Cajun Chicken Spaghetti in Creamy Garlic Mozzarella Sauce is the perfect fusion of comfort and bold flavor. It brings together tender pasta coated in a luscious garlic mozzarella sauce and spiced Cajun chicken that’s pan-seared to juicy perfection. The creamy base softens the kick of the Cajun seasoning, creating a balanced, irresistible bite.

Whether you’re serving this up for a cozy family dinner or impressing guests at a gathering, this dish delivers every time. It’s hearty enough to satisfy a hungry crowd but still easy enough to whip up on a busy weeknight. Once you try it, it might just become your new pasta night favorite.

Why You’ll Love This Cajun Chicken Spaghetti

This recipe nails the contrast between spicy and creamy in a way that feels indulgent but not overwhelming. The Cajun seasoning adds that bold, smoky heat, while the garlic mozzarella sauce cools it down with a silky texture and rich flavor.

It’s a great way to turn basic pantry staples like spaghetti and chicken into a standout dish. Plus, it’s incredibly customizable. Want more heat? Add red pepper flakes. Craving extra creaminess? A splash of heavy cream will do the trick. It’s endlessly adaptable, yet always delicious.

What Kind of Chicken Should I Use?

Boneless, skinless chicken breasts or thighs are both great choices for this dish. Breasts are leaner and cook quickly, while thighs offer more richness and moisture. Just make sure to slice the chicken thinly for even cooking and maximum flavor absorption. If you’re in a hurry, pre-cooked rotisserie chicken tossed in Cajun seasoning can work in a pinch too.

Ingredients for the Cajun Chicken Spaghetti in Creamy Garlic Mozzarella Sauce

To make this dish as flavorful as possible, each ingredient plays a key role. The Cajun seasoning brings that signature smoky spice, while the mozzarella and garlic create a velvety sauce that clings beautifully to the pasta. Fresh herbs and aromatics elevate everything with bright, vibrant notes.

• Spaghetti
• Boneless Chicken Breast or Thighs
• Cajun Seasoning
• Garlic Cloves
• Butter
• Heavy Cream
• Mozzarella Cheese
• Parmesan Cheese
• Chicken Broth
• Olive Oil
• Salt and Pepper
• Fresh Parsley (optional)

How To Make the Cajun Chicken Spaghetti in Creamy Garlic Mozzarella Sauce

Step 1: Season and Sear the Chicken

Season the chicken generously with Cajun seasoning, salt, and pepper. Heat olive oil in a skillet and sear the chicken until golden and cooked through. Set aside and let it rest before slicing.

Step 2: Cook the Spaghetti

Boil a pot of salted water and cook the spaghetti according to package instructions. Drain and reserve about a cup of pasta water.

Step 3: Make the Creamy Garlic Mozzarella Sauce

In the same skillet, melt butter and sauté minced garlic until fragrant. Stir in the chicken broth and heavy cream, bringing it to a gentle simmer. Add mozzarella and Parmesan cheeses, stirring until melted and smooth.

Step 4: Combine Everything

Toss the cooked spaghetti into the sauce, adding pasta water as needed for a silky consistency. Add the sliced Cajun chicken on top and stir to coat. Adjust seasoning if needed.

Step 5: Garnish and Serve

Finish with fresh parsley if desired, and serve hot while the sauce is deliciously creamy and the chicken is still juicy.

Watch Out for These Mistakes While Cooking

Don’t let a few common missteps get in the way of this dish’s full potential. First, don’t overcook the chicken; it should be seared until golden but still juicy inside. Second, avoid letting the garlic burn—it should be gently sautéed until fragrant, not browned. Also, resist the urge to add too much Cajun seasoning early on. You can always build more spice, but you can’t take it back.

Another tip: when adding cheese to the sauce, make sure the heat is low. High heat can cause the sauce to break or become grainy. Let it melt slowly into the cream for the smoothest texture.

How to Serve and Store Cajun Chicken Spaghetti in Creamy Garlic Mozzarella Sauce

This dish serves about four hearty portions, perfect for a family dinner or a couple of satisfying leftovers. Serve it hot right after it’s tossed with the sauce for the creamiest results. If you’re prepping in advance, keep the pasta and sauce separate until you’re ready to serve. Reheat gently on the stove with a splash of broth or cream to bring the sauce back to life.

For storage, refrigerate leftovers in an airtight container for up to 3 days. Avoid microwaving it directly from the fridge—warming it slowly ensures the sauce stays smooth.

What to Serve With Cajun Chicken Spaghetti?

Garlic Bread

Crispy, buttery garlic bread is ideal for soaking up every last drop of that creamy sauce.

Simple Green Salad

A refreshing salad with lemon vinaigrette balances the richness of the pasta.

Roasted Broccoli

The slight char and crunch of roasted broccoli pairs beautifully with the creamy textures.

Sauteed Spinach

Quickly wilted spinach with a touch of garlic keeps things simple and nutrient-packed.

Cornbread Muffins

For a Southern-inspired twist, pair with sweet and savory cornbread muffins.

Cucumber Tomato Salad

Cool, crunchy, and fresh—it’s a perfect contrast to the warm spice.

Grilled Asparagus

A light and earthy side dish that complements the bold Cajun flavor.

Lemon Butter Zucchini

Bright and buttery, zucchini cuts through the richness with just the right amount of zing.

Want More Chicken Pasta Ideas?

If you loved this Cajun Chicken Spaghetti in Creamy Garlic Mozzarella Sauce, you’ll definitely want to check out these equally satisfying favorites:

• Marry Me Chicken Pasta for a saucy, romantic dinner night.
• Creamy Crockpot Chicken Spaghetti for a no-fuss weeknight dinner.
• Creamy Garlic Chicken Breasts if you’re in the mood for skillet simplicity.
• One Pan Chicken with Buttered Noodles when you need dinner done with less cleanup.
• Creamy Garlic Butter Chicken Rotini for an extra dose of Parmesan indulgence.

Save This Recipe For Later

📌 Save this recipe to your Pinterest dinner board so you can revisit it any time you’re craving bold and creamy comfort.

And when you make it, tell me how it went in the comments. Did you double up on the garlic? Toss in some mushrooms? Add extra heat?

I love hearing your kitchen spins and swaps. Ask away if you’ve got questions—let’s make cooking a conversation.

Explore more weeknight magic and flavor-packed creations on Nina Dishes on Pinterest—your next favorite is waiting.

Conclusion

This Cajun Chicken Spaghetti in Creamy Garlic Mozzarella Sauce is what happens when fiery spice meets smooth, cheesy comfort. With a short ingredient list and a flavor profile that tastes like it took hours, it’s a weeknight winner that doesn’t skimp on excitement. Whether you’re cooking for a crowd or just spicing up your usual pasta rotation, this dish brings the heat—and the comfort.

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