Creamy Cajun Beef Spaghetti with Three-Cheese Parmesan Sauce

WANT TO SAVE THIS RECIPE?

Bold, creamy, and full of deep southern comfort, this Creamy Cajun Beef Spaghetti with Three-Cheese Parmesan Sauce is not your average pasta dinner. It combines tender ground beef spiced with smoky Cajun seasoning, perfectly cooked spaghetti noodles, and a velvety cheese sauce made from a trio of cheeses. Every bite delivers richness balanced with a spicy kick, giving you the ultimate weeknight indulgence.

This dish was born out of craving something that felt hearty like a casserole but creamy like alfredo, with the bonus of a little heat. It’s one of those meals that makes people pause mid-bite to ask, “Wait, what is in this?!” because it tastes like a fusion of all your favorite comfort food dishes in one.

Why You’ll Love This Creamy Cajun Beef Spaghetti

You’ll fall in love with this dish because it’s easy, deeply flavorful, and incredibly satisfying. The Cajun spices bring warmth without overpowering, and the three-cheese sauce is irresistibly smooth and savory. It’s an ideal meal when you want comfort food with personality.

Also, this recipe comes together in under an hour, making it a fantastic option for busy nights when you still want something homemade. It’s the kind of dish that gets better the next day, so leftovers (if there are any) are just as delicious.

What Kind of Pasta Should I Use for Cajun Beef Spaghetti?

Spaghetti noodles are the perfect choice for this dish because they soak up the sauce beautifully while keeping just the right amount of bite. However, you can also try fettuccine, linguine, or even penne if you prefer a chunkier pasta. The key is to go for something sturdy enough to handle the creamy cheese sauce and hearty beef without getting soggy or lost in the mix.

Ingredients for the Creamy Cajun Beef Spaghetti

When it comes to building bold flavors, each ingredient in this dish serves a delicious purpose. The Cajun seasoning adds smokiness and depth, while the cheeses work together to create a silky, savory sauce that ties everything together. Choose fresh, good-quality ingredients for the best results.

• Ground beef
• Spaghetti noodles
• Cajun seasoning
• Butter
• Garlic
• All-purpose flour
• Milk
• Heavy cream
• Parmesan cheese
• Cream cheese
• Mozzarella cheese
• Salt and black pepper
• Parsley (optional for garnish)

How To Make the Creamy Cajun Beef Spaghetti

Step 1: Cook the Pasta

Bring a large pot of salted water to a boil. Add spaghetti and cook according to package instructions until al dente. Drain and set aside.

Step 2: Brown the Beef

In a large skillet over medium heat, cook the ground beef until browned and cooked through. Drain any excess fat, season with Cajun seasoning, and set aside.

Step 3: Make the Cheese Sauce Base

In the same skillet, melt butter and sauté minced garlic until fragrant. Whisk in the flour and cook for a minute to eliminate the raw taste. Slowly pour in milk and heavy cream, whisking constantly to avoid lumps.

Step 4: Add the Cheese Trio

Lower the heat and stir in Parmesan, cream cheese, and mozzarella. Continue stirring until the cheese is melted and the sauce is smooth. Season with salt and black pepper to taste.

Step 5: Combine and Serve

Add the cooked spaghetti and seasoned beef back into the skillet. Toss to coat everything in the creamy sauce. Serve warm and top with freshly chopped parsley if desired.

Watch Out for These Mistakes While Cooking

Even the simplest dishes can go sideways if you’re not paying attention. For this recipe, avoid overcooking the pasta, as it will continue to soften slightly when tossed in the hot cheese sauce. Another common pitfall is using too much Cajun seasoning too early—you want it to complement, not overpower. Lastly, make sure the cheese sauce is cooked on low heat after adding the cheeses to avoid graininess or curdling.

How to Serve and Store Creamy Cajun Beef Spaghetti

This recipe serves about 4 to 6 people, making it a fantastic option for families or anyone who loves leftovers. Serve it piping hot straight from the skillet, ideally with a side of crusty garlic bread or a simple green salad.

If you have leftovers, store them in an airtight container in the fridge for up to 4 days. Reheat on the stove over low heat, adding a splash of milk or cream to bring the sauce back to life.

What to Serve With Creamy Cajun Beef Spaghetti?

Garlic Bread with Herb Butter

Its crispy edges and rich butter blend perfectly with the creamy pasta.

Caesar Salad

A crisp, tangy salad brings balance to the richness of the cheese sauce.

Sautéed Green Beans

Lightly cooked with garlic and lemon zest for a refreshing side.

Roasted Brussels Sprouts

Their caramelized flavor contrasts beautifully with the creamy texture of the pasta.

Cornbread Muffins

For a sweet, southern-style twist that plays well with the Cajun heat.

Cucumber and Tomato Salad

Simple, cooling, and fresh—exactly what you need to cleanse the palate.

Spicy Pickled Okra

Adds a fun zing that complements the dish’s Cajun profile.

Iced Sweet Tea or Lemonade

To wash it all down with a classic Southern drink that cools and refreshes.

Want More Pasta Dinner Ideas?

If this spicy, creamy Cajun spaghetti won your heart, there are more pasta delights you need to try next:

• Creamy Garlic Butter Chicken Rotini in Parmesan Sauce for another rich, cheesy combo with a garlicky punch.
• Creamy Tuscan Sausage Pasta if you’re craving sun-dried tomatoes and Italian comfort.
• Sour Cream Beef Noodle Casserole which gives you another creamy beefy dish with a classic twist.
• One Pot Creamy Beef and Garlic Butter Pasta when you want a simple but flavor-packed one-pot wonder.

Save This Recipe For Later

📌 Save this recipe to your Pinterest dinner board so you can come back to it any time.

And let me know in the comments how yours turned out. Did you crank up the heat or go lighter on the spice? Add some veggies or sneak in extra cheese?

I love seeing the ways you make these recipes your own. Feel free to drop your questions below too—we’re here to help each other make magic in the kitchen.

Explore beautifully curated health-boosting drinks on Nina Dishes on Pinterest and discover your new go-to for feeling great!

Conclusion

Creamy Cajun Beef Spaghetti with Three-Cheese Parmesan Sauce is pure Southern-style indulgence. With bold spices, hearty beef, and a luscious cheese sauce clinging to every strand of pasta, it’s a dish that brings warmth to any night of the week. Whether you’re cooking for a crowd or meal-prepping for the week, this is a recipe worth bookmarking—and sharing.

Print

WANT TO SAVE THIS RECIPE?