Creamy Cajun Chicken Fettuccine with Garlic Mozzarella Cheese Sauce

WANT TO SAVE THIS RECIPE?

Imagine twirling your fork into a silky fettuccine noodle coated in a rich, garlicky mozzarella cheese sauce with just the right kick of Cajun spice. This dish is the ultimate comfort food with a spicy edge, perfect for a cozy dinner or when you’re craving something hearty and indulgent.

This creamy Cajun chicken fettuccine brings together bold flavors and creamy textures in a way that feels both luxurious and homey. Tender slices of chicken seasoned with smoky Cajun spices rest atop a bed of pasta that soaks up every bit of that creamy garlic mozzarella sauce. It’s a fusion of Southern heat and Italian comfort that you won’t want to miss.

Why You’ll Love This Creamy Cajun Chicken Fettuccine

This dish delivers serious flavor with minimal fuss. The spicy Cajun seasoning perfectly balances the creamy mozzarella garlic sauce, creating a dish that’s rich but not overwhelming. It’s also a crowd-pleaser and feels fancy enough for guests, yet simple enough for a weeknight meal.

The best part? It’s a one-pan kind of dish that doesn’t require too much prep, which means less cleanup and more time to enjoy the deliciousness. Whether you’re feeding a hungry family or cooking for two, this meal satisfies on every level.

What Kind of Cajun Seasoning Should I Use?

You can go for a store-bought Cajun seasoning blend, which is super convenient, or you can mix your own using paprika, garlic powder, onion powder, thyme, oregano, cayenne, and a bit of salt and pepper. If you like it hot, feel free to increase the cayenne. The homemade route gives you full control over the spice level and flavor profile, but honestly, even a quality pre-mixed version will work wonders in this recipe.

Ingredients for the Creamy Cajun Chicken Fettuccine

The beauty of this dish lies in how each ingredient plays a role in layering flavor and texture. The Cajun spices bring the heat, the mozzarella adds melty richness, and the garlic ties everything together with its aromatic charm. Here’s what you’ll need:

• Chicken breasts
• Cajun seasoning
• Fettuccine pasta
• Garlic cloves
• Butter
• Heavy cream
• Mozzarella cheese
• Parmesan cheese
• Salt and black pepper
• Olive oil
• Fresh parsley

How To Make the Creamy Cajun Chicken Fettuccine

Step 1: Season and Cook the Chicken

Start by slicing your chicken breasts into thin strips. Season generously with Cajun seasoning. Heat olive oil in a large skillet over medium-high heat and sear the chicken until golden brown and cooked through. Remove and set aside.

Step 2: Cook the Pasta

While the chicken is cooking, boil a large pot of salted water. Add fettuccine and cook until al dente. Reserve a cup of pasta water before draining.

Step 3: Make the Garlic Mozzarella Sauce

In the same skillet used for the chicken, melt butter and sauté minced garlic until fragrant. Pour in the heavy cream, bring to a gentle simmer, and stir in mozzarella and Parmesan until melted and smooth.

Step 4: Combine Everything

Add the cooked fettuccine to the sauce, tossing to coat. If needed, add reserved pasta water a little at a time to loosen the sauce. Return the chicken to the skillet and stir everything together until warmed through.

Step 5: Garnish and Serve

Top with chopped parsley and an extra sprinkle of Parmesan before serving. Enjoy the creamy, spicy, cheesy deliciousness!

Watch Out for These Mistakes While Cooking

The key to nailing this dish lies in balancing the bold flavors with the creamy base. One of the most common mistakes is overcooking the chicken, which can make it dry and rubbery. Cook just until it’s no longer pink and has a good sear.

Another slip-up is letting the sauce boil too hard. High heat can cause the cream to split and the cheese to become gritty. Keep your heat on low to medium when making the sauce, and stir gently for a silky consistency.

Also, don’t skip the pasta water. It’s a little trick that helps bind the sauce to the noodles and gives that glossy restaurant-style finish.

Serving and Storing This Creamy Cajun Chicken Fettuccine

This recipe feeds about 4 to 5 people generously. Serve it fresh and hot straight from the skillet for the best taste and texture. If you want to impress guests, top each serving with a sprig of parsley and a little extra grated Parmesan.

To store leftovers, let the dish cool completely, then transfer to an airtight container. It will keep in the fridge for up to 3 days. When reheating, add a splash of milk or cream to revive the sauce and heat gently to avoid separation.

What to Serve With Creamy Cajun Chicken Fettuccine?

Garlic Bread

Nothing beats a slice of crispy garlic bread to scoop up every drop of that luscious cheese sauce.

Simple Green Salad

A light salad with vinaigrette balances the richness of the pasta and adds a refreshing crunch.

Roasted Broccoli

The earthy, crispy bits of roasted broccoli pair wonderfully with creamy pasta.

Sautéed Spinach

Quick-cooked spinach with a hint of lemon or garlic lightens up the plate without overpowering it.

Grilled Corn on the Cob

Sweet and smoky grilled corn adds a fun, summery contrast to the dish.

Tomato Basil Soup

A warm bowl of this simple soup makes for a comforting start to your Cajun feast.

Sparkling Lemon Water

For a drink, serve sparkling lemon water to cut through the richness with a citrusy zing.

Want More Pasta Dinner Ideas?

If you love this Creamy Cajun Chicken Fettuccine, here are more flavor-packed dinners you’ll want to try:

• Creamy Tuscan Sausage Pasta for a sun-dried tomato and spinach twist.
• Creamy Garlic Butter Chicken Rotini in Parmesan Sauce if you’re craving more garlicky goodness.
• Copycat Olive Garden Ravioli Carbonara for a restaurant-style comfort meal at home.
• [Creamy Cajun Steak Alfredo](https://ninadishes.com/cream
y-cajun-steak-alfredo/) when you’re in the mood for beef with spice.
• One Pot Creamy Beef and Garlic Butter Pasta for an all-in-one creamy skillet dinner.

Save This Recipe For Later

📌 Save this recipe to your Pinterest dinner board so you can come back to it any time.

And let me know in the comments how yours turned out. Did you go all-in on the Cajun spice? Did you sneak in veggies or extra cheese?

I love hearing how others make these recipes their own. Questions are welcome too – let’s help each other cook better every day.

Explore beautifully curated health-boosting drinks on Nina Dishes on Pinterest and discover your new go-to for feeling great!

Conclusion

Creamy Cajun Chicken Fettuccine with Garlic Mozzarella Cheese Sauce is one of those meals that feels like a restaurant treat but is entirely doable at home. The blend of spice, creaminess, and savory depth makes every bite unforgettable.

Whether you’re feeding your family or cooking to impress, this pasta brings comfort and flavor to the table with zero fuss.

Print

WANT TO SAVE THIS RECIPE?