Creamy Cajun Chicken Rotini with Mozzarella Alfredo Sauce

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This Creamy Cajun Chicken Rotini with Mozzarella Alfredo Sauce is a bold, comforting twist on your usual pasta dinner. With juicy chicken breast, rotini pasta, and a spicy Cajun flair balanced by a rich, cheesy Alfredo sauce, every bite is like a creamy Cajun dream come true. It’s a dish that satisfies both the spice lover and the cheese enthusiast in one go.

Whether you’re whipping it up for a busy weeknight or impressing guests on the weekend, this dish has the wow-factor without the hassle. Rotini perfectly hugs the sauce, while mozzarella adds that irresistible pull-apart goodness. If you’re a fan of heat with a creamy touch, this might just become your new favorite pasta recipe.

Why You’ll Love This Creamy Cajun Chicken Rotini

It’s indulgent but easy. The Cajun spice gives it just the right amount of kick without overwhelming your taste buds. Plus, the mozzarella Alfredo sauce is incredibly smooth, thanks to a combination of melty cheese and cream that coats the pasta beautifully. It’s the kind of meal that turns an ordinary evening into something special with very little effort.

If you enjoy a dish that balances heat, creaminess, and savory satisfaction, this one brings it all together in a single pan.

What Kind of Cajun Seasoning Should I Use?

You can use any store-bought Cajun seasoning blend you like, but look for one that doesn’t list salt as the first ingredient—this helps you control the salt level in your dish. If you prefer homemade, a mix of paprika, garlic powder, onion powder, cayenne, oregano, and thyme works beautifully. Some blends are heavier on heat, others lean smokier, so feel free to experiment until you find one that suits your palate.

Ingredients for the Creamy Cajun Chicken Rotini with Mozzarella Alfredo Sauce

To make this creamy and spicy pasta dish shine, the right ingredients are key. Each component plays an important role in building layers of flavor and richness. Let’s break down what you’ll need to bring this comforting meal to life:

• Chicken breast: Boneless and skinless, sliced into bite-sized pieces. This is your main protein and soaks up all the Cajun flavor.
• Rotini pasta: The spiral shape is perfect for holding onto the creamy Alfredo sauce.
• Cajun seasoning: Adds spice and depth, infusing the chicken with bold Southern heat.
• Garlic: Fresh minced garlic builds a flavorful base.
• Butter: Used for sautéing and building the Alfredo sauce.
• Heavy cream: Essential for that thick, luxurious Alfredo texture.
• Mozzarella cheese: Melts into the sauce for that perfect gooey finish.
• Parmesan cheese: Adds a salty, nutty balance to the mozzarella.
• Salt and black pepper: To season everything just right.
• Olive oil: Helps sear the chicken and keep it juicy.
• Parsley (optional): For a fresh pop of color and a hint of herbaceous finish.

How To Make the Creamy Cajun Chicken Rotini with Mozzarella Alfredo Sauce

Step 1: Cook the Pasta

Boil a large pot of salted water and cook the rotini pasta according to the package directions until al dente. Drain and set aside.

Step 2: Sear the Chicken

Heat olive oil in a skillet over medium-high heat. Season the chicken with Cajun seasoning, salt, and pepper. Sear until golden brown and cooked through, about 5–7 minutes. Remove and set aside.

Step 3: Make the Alfredo Base

In the same pan, melt butter and add minced garlic. Cook for about 1 minute until fragrant. Pour in the heavy cream and bring to a gentle simmer.

Step 4: Add the Cheese

Gradually whisk in mozzarella and Parmesan cheese until fully melted and smooth. Adjust seasoning with more salt or pepper if needed.

Step 5: Combine Everything

Add the cooked rotini and seared chicken into the sauce. Toss well to coat every piece in that rich, cheesy goodness. Simmer for a couple of minutes to meld flavors.

Step 6: Serve

Garnish with chopped parsley if desired and serve hot straight from the pan.

Watch Out for These Mistakes While Cooking

This dish is straightforward, but a few common pitfalls can turn creamy into clumpy or flavorful into flat. Overcooking the pasta is a big one—rotini should be al dente so it doesn’t become mushy once it meets the sauce. Also, make sure not to overheat the Alfredo base; high heat can cause the cream to separate or the cheese to become gritty.

Another important tip: season the chicken generously with Cajun spice before cooking. If it’s under-seasoned, the entire dish can feel like it’s missing its kick. Finally, don’t rush the cheese melting step—slow and steady makes the sauce silky.

How to Serve and Store This Creamy Cajun Chicken Rotini with Mozzarella Alfredo Sauce

This pasta is rich and satisfying enough to be served on its own, but it also pairs wonderfully with a simple green salad or crusty garlic bread. The recipe feeds 4 people generously, making it great for family dinners or meal prep.

To store leftovers, let the pasta cool completely and transfer it to an airtight container. It will keep in the fridge for up to 3 days. Reheat gently on the stovetop or in the microwave with a splash of cream or milk to revive the sauce.

What to Serve With Creamy Cajun Chicken Rotini?

Garlic Bread

The perfect companion to soak up every drop of that creamy Alfredo sauce.

Steamed Broccoli

The freshness and slight crunch contrast nicely with the creamy richness of the pasta.

Caesar Salad

A chilled Caesar salad adds a crisp, tangy balance.

Roasted Vegetables

Try roasted bell peppers or asparagus to bring some earthy notes to the plate.

Cornbread Muffins

A touch of Southern charm that complements the Cajun spices.

Grilled Zucchini

A light and smoky side dish that pairs well with creamy pastas.

Avocado Slices

The creaminess of avocado with a sprinkle of sea salt makes a surprising and delicious combo.

Sparkling Lemon Water

For a refreshing contrast and to cleanse the palate between bites.

Want More Pasta Ideas?

If you can’t get enough of comforting, creamy pasta dishes, these will be right up your alley:

• Marry Me Chicken Pasta has a romantic twist and a sun-dried tomato kick.
• Creamy Tuscan Sausage Pasta if you love bold Italian flavors.
• Creamy Garlic Chicken Breasts for something that pairs beautifully with any type of pasta.
• Creamy Crockpot Chicken Spaghetti when you want that cozy taste with less hands-on time.
• One-Pan Creamy Chicken Pot Pie Pasta for a dish that feels like a warm hug.

Save This Recipe For Later

📌 Save this recipe to your Pinterest dinner board so you can come back to it any time.

And let me know in the comments how yours turned out. Did you make it extra spicy? Did you add mushrooms or spinach?

I love seeing how others put their own spin on my recipes. Feel free to drop any questions too—we’re in this cooking journey together.

Explore beautifully curated dinner and comfort food ideas on Nina Dishes on Pinterest and discover your new weeknight favorite!

Conclusion

Creamy Cajun Chicken Rotini with Mozzarella Alfredo Sauce is the kind of pasta dish that satisfies every craving in one bowl. It’s spicy, it’s creamy, and it’s got that irresistible cheesy pull that makes every forkful better than the last. Whether it’s a casual Tuesday or a dinner party with friends, this recipe brings flavor and comfort to the table with minimal effort.

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