Creamy Chicken and Spinach Casserole

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This creamy chicken and spinach casserole was born out of a craving for something hearty, comforting, and just a little indulgent. I wanted a dish that would feel like a warm hug at the end of a busy day, yet still pack in enough greens to make me feel virtuous. The first time I made it, the golden crust bubbling with creamy sauce was enough to bring everyone to the kitchen before I even called them to the table.

The magic of this casserole lies in its balance. Tender pieces of chicken are wrapped in a rich, garlicky sauce, which is perfectly offset by the earthy freshness of spinach. The layers come together under a blanket of cheese that melts and browns just right in the oven. It’s the kind of dish that disappears fast, with people going back for seconds and asking for the recipe.

What I love most is how it satisfies without feeling too heavy. It’s loaded with flavor and makes excellent leftovers, though that’s rare in my house. Whether you’re cooking for a crowd or prepping meals for the week, this creamy chicken and spinach casserole is a dependable go-to. For more creamy inspiration, check out my recipes for Creamy Garlic Chicken Breasts and Creamy Tuscan Sausage Pasta.

Why You’ll Love This Creamy Chicken and Spinach Casserole

It’s comfort food at its best, with a creamy sauce that clings to every bite of tender chicken. Spinach adds a nutritious punch, and the dish bakes into a beautifully golden top that’s both crispy and gooey. It’s easy to prepare and just as easy to devour. Plus, it works equally well as a main course for family dinner or a potluck favorite that steals the spotlight.

Ingredients

Chicken breast is the protein foundation of this dish, offering a lean, tender bite that soaks up all the creamy flavors. Fresh spinach brings a subtle earthiness and vibrant green color, adding both nutrition and balance to the richness. Cream cheese is what makes the casserole luxuriously creamy and helps everything hold together. Mozzarella cheese delivers that melty, stretchy top layer everyone craves in a baked dish. Garlic enhances the overall flavor profile, giving the sauce depth and warmth. Finally, a touch of chicken broth helps thin out the sauce just enough so it coats the ingredients without becoming soupy.

How to Make Creamy Chicken and Spinach Casserole

Step 1: Prepare the Chicken

Start by cooking the chicken breasts. You can either pan-sear them with olive oil and garlic or use pre-cooked shredded chicken for convenience. Either way, make sure the chicken is cooked through and chopped or shredded into bite-sized pieces.

Step 2: Make the Creamy Sauce

In a large skillet over medium heat, combine cream cheese, garlic, and chicken broth. Stir until the cream cheese melts and the sauce becomes smooth. Let it simmer briefly to meld the flavors.

Step 3: Add Spinach

Toss in fresh spinach and stir until wilted. The heat from the sauce should be enough to soften it down nicely without turning it mushy. This gives the dish a lovely color and earthy flavor.

Step 4: Combine Ingredients

Add the cooked chicken into the skillet with the sauce and spinach. Mix until everything is well coated. Taste and season with salt and pepper as needed.

Step 5: Assemble and Bake

Transfer the mixture into a greased baking dish. Sprinkle the top generously with mozzarella cheese. Bake at 375°F (190°C) for 20-25 minutes or until the top is bubbly and golden brown.

Step 6: Serve and Enjoy

Let the casserole sit for 5 minutes before serving. This helps it set and makes for cleaner slices. Serve it warm and enjoy the creamy, savory layers in every bite.

Recipe Variations and Possible Substitutions

There are plenty of ways to customize this creamy chicken and spinach casserole to suit your preferences. Swap the chicken breasts for rotisserie chicken if you’re short on time, or use turkey for a leaner twist. You can also substitute the cream cheese with sour cream or Greek yogurt for a lighter, tangier base. If you’re looking for a different green, try kale or Swiss chard in place of spinach. Mozzarella cheese can be replaced with Monterey Jack or even a sharp cheddar for added depth.

Want a low-carb version? Skip the pasta or rice sides and mix in cauliflower rice directly into the casserole. Craving a crunchy topping? Add a layer of breadcrumbs or crushed crackers mixed with melted butter before baking for that golden finish.

Serving and Pairing Suggestions

This casserole is hearty enough to stand alone, but it pairs wonderfully with simple sides. Serve it with a fresh green salad tossed in lemon vinaigrette or some roasted vegetables like carrots or Brussels sprouts. If you prefer a heartier meal, spoon it over mashed potatoes, rice, or buttered noodles.

To round out your meal, try a light dessert like fresh fruit or something indulgent like Cherry Chocolate Cheesecake.

Storage and Reheating Tips

Store any leftovers in an airtight container in the refrigerator for up to 3 days. When ready to eat, reheat individual servings in the microwave for 1-2 minutes, or warm the entire casserole in the oven at 350°F until heated through.

For freezing, let the casserole cool completely, then wrap tightly with foil or plastic wrap and freeze for up to 2 months. Thaw overnight in the fridge before reheating.

FAQs

Can I make Creamy Chicken and Spinach Casserole ahead of time?

Absolutely. Assemble the casserole and cover it tightly. Store it in the fridge for up to 24 hours before baking. You may need to add 5-10 minutes to the baking time if it’s going straight from the fridge to the oven.

What can I use instead of cream cheese in Creamy Chicken and Spinach Casserole?

You can substitute with sour cream or Greek yogurt for a slightly tangier and lighter version. A bechamel sauce also works if you prefer something more traditional.

Is Creamy Chicken and Spinach Casserole keto-friendly?

Yes, with a few tweaks. Replace the cream cheese with a full-fat version, skip any carb-heavy sides, and make sure to use only low-carb veggies like spinach or kale.

Can I freeze Creamy Chicken and Spinach Casserole?

Definitely. Once cooled, wrap it well and store in the freezer for up to 2 months. Thaw in the fridge overnight before reheating in the oven or microwave.

Related Recipe You’ll Like

If you love the cozy comfort of casseroles, you won’t want to miss the Chicken Cordon Bleu Casserole. It has the same creamy, cheesy goodness with a crispy topping, plus that irresistible ham and Swiss combination that always hits the spot. For more veggie-forward meals, check out White Sauce Zucchini Spinach Lasagna.

Save and Share This Recipe for Later

Don’t forget to save this creamy chicken and spinach casserole recipe to your Pinterest board so you can easily find it again when the craving hits. If you made it and loved it, share the link with your friends or post a picture on your social media. Tag me so I can see your delicious creations!

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