Mexican Lasagna Layered Beef Casserole

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If you’re looking for a comforting dinner that combines bold flavors and creamy layers, this Mexican Lasagna Layered Beef Casserole is your next favorite. Packed with seasoned beef, melty cheese, and soft tortillas, it’s a delicious twist on a classic Italian lasagna that brings a fiesta to your table. Each bite is hearty, spicy, and irresistibly cheesy, making it perfect for weeknights or a casual dinner party.

What makes this dish so appealing is its simplicity and flexibility. You can easily adjust the spice level to suit your taste or swap in ground turkey or chicken for a lighter version. Plus, it reheats beautifully, so you can enjoy leftovers just as much the next day.

Why You’ll Love This Mexican Lasagna Layered Beef Casserole

This casserole is perfect when you need a dish that’s both satisfying and easy to make ahead. The flavors meld together as it bakes, creating a warm, comforting meal everyone will rave about. Whether you serve it as a main for your family or take it to a potluck, it’s sure to please.

What Kind of Tortillas Should I Use?

For the best texture, soft flour tortillas are recommended for this recipe. They soak up the sauce nicely while keeping their structure, giving you perfect layers that hold together when sliced. You can also use corn tortillas if you prefer a more authentic, slightly chewy bite with a hint of sweetness.

Ingredients for the Mexican Lasagna Layered Beef Casserole

To create this flavorful casserole, you’ll need a few pantry staples and fresh ingredients. Each layer adds its own unique flavor and texture, so using fresh, quality ingredients really elevates the dish.

• Ground beef: Provides a hearty, savory base.
• Flour tortillas: Create the soft, layered structure of the casserole.
• Shredded cheese: Melts into creamy, cheesy layers.
• Enchilada sauce: Adds tangy and spicy moisture to the dish.
• Black beans: Bring an earthy flavor and extra protein.
• Corn: Adds sweetness and texture.
• Onion: For a mild bite and depth of flavor.
• Garlic: Infuses aromatic richness.
• Taco seasoning: Brings all the spices together for a Mexican-inspired flavor.
• Fresh cilantro: For a bright, fresh finish.

How To Make the Mexican Lasagna Layered Beef Casserole

Step 1: Cook the Beef Filling

In a skillet over medium heat, sauté diced onion and minced garlic until fragrant. Add the ground beef and cook until browned. Stir in taco seasoning, black beans, and corn, mixing well. Remove from heat.

Step 2: Layer the Casserole

Preheat your oven to 350°F. In a 9×13-inch baking dish, spread a thin layer of enchilada sauce. Place a layer of tortillas over the sauce, followed by a portion of the beef mixture, a drizzle of enchilada sauce, and a sprinkle of shredded cheese. Repeat layers until all ingredients are used, finishing with cheese on top.

Step 3: Bake to Perfection

Cover the dish with foil and bake for 20 minutes. Remove the foil and bake an additional 10 minutes until the cheese is golden and bubbly.

Step 4: Garnish and Serve

Remove from the oven and let it cool slightly. Garnish with fresh cilantro before slicing and serving.

Watch Out for These Mistakes While Cooking

Even though this casserole is straightforward to prepare, a few common mistakes can impact your results. Make sure not to skip draining excess grease from the cooked beef; otherwise, the casserole can turn greasy. Don’t over-saturate the tortillas with sauce — they should be moist but not soggy. Finally, allow the casserole to rest for a few minutes after baking so it slices cleanly and layers hold together.

How to Serve and Store This Mexican Lasagna Layered Beef Casserole

This dish serves 6 to 8 people, making it ideal for family dinners or casual entertaining. Serve warm straight from the oven, paired with fresh toppings like sour cream, avocado, or sliced jalapeños. If you have leftovers, store them in an airtight container in the fridge for up to 4 days. To reheat, simply warm slices in the oven or microwave until heated through.

What to Serve With Mexican Lasagna Layered Beef Casserole?

Mexican Rice

A fluffy, seasoned rice is a perfect complement to soak up the casserole’s sauces.

Refried Beans

Creamy and savory, refried beans add even more Mexican-inspired flavor to your plate.

Fresh Guacamole

Cool and creamy guacamole balances the spiciness of the casserole beautifully.

Salsa and Chips

For a little crunch and zest, a side of tortilla chips with fresh salsa is always welcome.

Simple Green Salad

A crisp salad with lime vinaigrette adds a refreshing, light contrast to the hearty casserole.

Roasted Vegetables

Colorful roasted peppers, zucchini, and onions bring a sweet, smoky note to the meal.

Want More Casserole Ideas?

If you love this Mexican Lasagna Layered Beef Casserole, you’ll probably enjoy these other comforting favorites:

• Cheesy Mexican Rice Casserole for another hearty Mexican-inspired bake.
• Chicken Cordon Bleu Casserole with creamy, cheesy layers.
• Taco Spaghetti Casserole that combines two family favorites.
• Easy Tuna Noodle Casserole for a nostalgic, creamy dish.
• The Ultimate Taco Casserole with bold spices and crispy toppings.

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And let me know in the comments how yours turned out. Did you add extra spice or go milder? Did you try a different protein?

I love hearing how others make these recipes their own. Questions are welcome too — let’s help each other cook smarter.

Explore beautifully curated dinner inspiration on Nina Dishes on Pinterest and discover your next go-to comfort food!

Conclusion

This Mexican Lasagna Layered Beef Casserole is the kind of dish that brings people together around the table. Comforting, flavorful, and easy to customize, it’s destined to become a regular in your dinner rotation. Give it a try and enjoy every cheesy, savory bite.

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