Chicken and Spinach Casserole with Cream Cheese

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I’ve made countless casseroles over the years, but this Chicken and Spinach Casserole with Cream Cheese stands out every single time. It’s rich, savory, and incredibly comforting. What makes it truly special is how it turns everyday ingredients into a warm, bubbly dish that feels like a hug in every bite. The creamy cheese blend, the tender chicken, and the nutritious spinach come together in the most satisfying way.

I first whipped this up on a chilly evening when I had chicken breasts, some fresh spinach, and a block of cream cheese just waiting to be turned into something special. I didn’t expect much, but one spoonful in and I was hooked. Now, it’s a staple in my kitchen—the kind of dish you make once and then crave for days afterward. My family loves it, and even picky eaters ask for seconds.

It’s also incredibly versatile. I’ve shared it at potlucks, taken it to new moms, and made it on lazy weeknights. Every single time, it’s a hit. Plus, it’s a breeze to prep. If you’re a fan of cheesy, hearty comfort food, then you’re going to adore this casserole. While you’re here, don’t miss out on my other creamy favorites like the Creamy Garlic Chicken Breasts or the equally cozy Creamy Tuscan Sausage Pasta.

Why You’ll Love This Chicken and Spinach Casserole with Cream Cheese

This dish checks every box when it comes to an easy, delicious dinner. The cream cheese makes the sauce ultra-luxurious, without needing a ton of prep. It’s also a one-dish meal, packed with protein from the chicken and greens from the spinach, which means fewer dishes and more time to enjoy your evening.

You’ll love how simple it is to customize—whether you want to toss in extra veggies, swap cheeses, or use rotisserie chicken to save time. Best of all, it reheats beautifully, making leftovers just as good as the first time. It’s a practical, hearty, and downright delicious solution for busy nights or cozy weekends.

Ingredients

Chicken breast is essential for the protein base of this dish. It holds up well in baking and becomes wonderfully tender in the creamy sauce. Spinach brings in a pop of color and a healthy, earthy flavor that balances the richness. Cream cheese is the star of the show here, giving the casserole its signature smooth and tangy creaminess.

Mozzarella cheese melts into gooey strands that create that crave-worthy cheesy pull with every serving. Garlic adds aromatic depth and savory sharpness that ties everything together. Onion enhances the flavor with its sweet undertone, while olive oil helps saute the base ingredients to golden perfection. Salt and pepper round out the seasoning, ensuring every bite is perfectly balanced.

How to make the Chicken and Spinach Casserole with Cream Cheese

Step 1: Preheat and Prepare

Preheat your oven to 375°F (190°C). Lightly grease a baking dish with olive oil or cooking spray. This ensures nothing sticks and makes cleanup easier.

Step 2: Cook the Aromatics

In a large skillet over medium heat, warm some olive oil. Add diced onions and cook until soft and translucent. Stir in the minced garlic and cook until fragrant, about 30 seconds.

Step 3: Add Chicken

Dice your chicken breasts and add them to the skillet. Season with salt and pepper. Cook until the chicken is no longer pink in the center. Remove from heat.

Step 4: Stir in the Cream Cheese

Cut the cream cheese into cubes and stir into the warm chicken mixture. Let it melt gently, stirring until it becomes a smooth, creamy sauce that coats the chicken evenly.

Step 5: Add Spinach

Add fresh spinach to the skillet and stir until it wilts into the creamy chicken mixture. If you’re using frozen spinach, make sure to thaw and drain it well before adding.

Step 6: Layer and Top

Transfer the mixture into your prepared baking dish. Spread it out evenly. Sprinkle a generous amount of shredded mozzarella cheese over the top.

Step 7: Bake

Bake uncovered for 20 to 25 minutes, or until the cheese is bubbly and golden brown. Let it cool for a few minutes before serving to allow everything to set perfectly.

Recipe Variations and Possible Substitutions

This casserole invites creativity. Instead of chicken breast, try shredded rotisserie chicken for extra convenience and flavor. If you prefer a meatless version, mushrooms or tofu work well and soak up the creamy sauce beautifully.

For cheese swaps, cheddar gives a sharp kick, while provolone adds a buttery melt. Greek yogurt or sour cream can replace some of the cream cheese for a slightly tangier bite. And feel free to sneak in extra veggies like bell peppers or zucchini—they blend right in without overpowering the main flavors.

Serving and Pairing Suggestions

Serve this Chicken and Spinach Casserole with Cream Cheese hot from the oven with a simple green salad or roasted vegetables for a balanced meal. It also pairs beautifully with crusty garlic bread or a side of buttery mashed potatoes.

For drinks, a chilled glass of white wine like Sauvignon Blanc or a crisp iced tea makes a great match. If you’re serving it for a gathering, pair it with lighter appetizers to let the casserole shine.

Storage and Reheating Tips

Once cooled, store leftovers in an airtight container in the refrigerator for up to 4 days. It also freezes well—wrap it tightly in foil and freeze for up to 2 months. Thaw overnight in the fridge before reheating.

To reheat, warm individual portions in the microwave in 1-minute intervals until heated through. For a full dish, cover with foil and bake at 350°F for about 20 minutes, or until warmed and bubbly.

FAQs

How do I keep my Chicken and Spinach Casserole with Cream Cheese from becoming watery?

Make sure to drain any excess liquid from the spinach, especially if you’re using frozen. Also, let the casserole sit for a few minutes after baking to allow it to set.

Can I make Chicken and Spinach Casserole with Cream Cheese ahead of time?

Yes, assemble the casserole up to the baking step, then cover and refrigerate for up to 24 hours. Bake when ready to serve.

What should I serve with Chicken and Spinach Casserole with Cream Cheese?

Light sides like a fresh salad, steamed broccoli, or garlic toast work perfectly to round out the meal.

Can I use low-fat cream cheese in Chicken and Spinach Casserole with Cream Cheese?

Absolutely. Low-fat cream cheese will still deliver creaminess, though the texture might be slightly less rich than the full-fat version.

Related Recipe You’ll Like

If you enjoyed this Chicken and Spinach Casserole with Cream Cheese, you’ll love exploring other creamy, cheesy favorites. My Creamy Garlic Chicken Breasts deliver the same savory comfort in a skillet version, while the Creamy Tuscan Sausage Pasta offers bold Italian flavors in every bite. And don’t miss the hearty Cheese Shrimp Penne Pasta with Spinach for a delightful seafood twist.

Save and Share This Recipe for Later

Don’t let this delicious casserole slip away—pin it on your Pinterest board to keep it handy for those busy nights when you need something comforting and quick. Share the recipe with friends and family who appreciate a good creamy casserole. Whether it’s a weeknight dinner or a weekend gathering, this is one dish that deserves a spot in everyone’s rotation.

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